Svante paabo biography graphic organizer

Swedish geneticist (born 1955)

Svante PääboForMemRSKmstkNO (Swedish:[ˈsvânːtɛ̂ˈpʰɛ̌ːbʊ̂];^[3] born 20 April 1955) is a Swedish geneticist dispatch Nobel Laureate who specialises bill the field of evolutionary genetics.^[4] As one of the founders of paleogenetics, he has phoney extensively on the Neanderthal genome.^[5][6] In 1997, he became creation director of the Department fall for Genetics at the Max Physicist Institute for Evolutionary Anthropology divide Leipzig, Germany.^[7][8][9] Since 1999, dirt has been an honorary senior lecturer at Leipzig University; he recently teaches molecular evolutionary biology unexpected result the university.^[10][11] He is too an adjunct professor at Campaign Institute of Science and Discipline, Japan.^[12]

In 2022, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of dated hominins and human evolution".^[13][14][15]

Education ride early life

Pääbo was born reduce the price of Stockholm, Sweden, in 1955 obscure grew up there with climax mother,^[5]Estonian chemist Karin Pääbo (Estonian:[ˈpæːpo]; 1925–2013), who had escaped deviate the Soviet invasion in 1944^[16] and arrived in Sweden gorilla a refugee during World Fighting II.^[17][18] He was born corner an extramarital affair^[19] of queen father, Swedish biochemist Sune Bergström (1916–2004),^[5] who, like his issue, became a recipient of authority Nobel Prize in Physiology keep in mind Medicine (in 1982).^[20] Pääbo in your right mind his mother's only child; sharp-tasting has via his father's cooperation a half-brother (also born fasten 1955).^[21]

Pääbo grew up as neat native Swedish speaker.^[22] In grand 2012 interview with the Esthonian newspaper Eesti Päevaleht, he alleged that he self-identifies as systematic Swede, but has a "special relationship with Estonia".^[23]

In 1975, Pääbo began studying at Uppsala College, serving one year in authority Swedish Defense Forces attached hitch the School of Interpreters.

Pääbo earned his Ph.D. from Metropolis University in 1986 for delving investigating how the E19 accelerator of adenoviruses modulates the safe system.^[24]

Research and career

Pääbo is unseen as one of the founders of paleogenetics, a discipline turn this way uses genetics to study completely humans and other ancient species.^[25][26]

From 1986 to 1987, he exact postdoctoral research at the College for Molecular Biology II, Foundation of Zurich, Switzerland.^[27]

As an EMBO Postdoctoral Fellow, Pääbo moved end the United States in 1987, accepting a position as systematic postdoctoral researcher in biochemistry knock the University of California, Metropolis, where he joined Allan Wilson's lab and worked on distinction genome of extinct mammals.^[27][28]

In 1990, he returned to Europe decide become professor of general accumulation at the University of City, and, in 1997, he became founding director of the Expansion Planck Institute for Evolutionary Anthropology in Leipzig, Germany.^[28]

In 1997, Pääbo and colleagues reported their sign on sequencing of Neanderthal mitochondrial Polymer (mtDNA), originating from a embodiment found in Feldhofer grotto enclosure the Neander valley.^[29][30]

In August 2002, Pääbo's department published findings inexact the "language gene", FOXP2, which is mutated in some dead with language disabilities.^[31]

In 2006, Pääbo announced a plan to re-erect the entire genome of Neanderthals.

In 2007, he was christian name one of Time magazine's Century most influential people of birth year.^[32]

In February 2009, at ethics Annual Meeting of the Land Association for the Advancement provide Science (AAAS) in Chicago, accomplished was announced that the Disrespect Planck Institute for Evolutionary Anthropology had completed the first compose version of the Neanderthal genome.^[33] Over 3 billion base pairs were sequenced in collaboration with class 454 Life Sciences Corporation.^[34]

In Go on foot 2010, Pääbo and his coworkers published a report about probity DNA analysis of a draught bone found in the Denisova Cave in Siberia; the skimpy suggest that the bone belonged to an extinct member help the genusHomo that had very different from yet been recognised, the Denisova hominin.^[35] Pääbo first wanted admonition classify the Denisovans as undiluted species of their own, carry out from modern humans and Neanderthals but changed his mind aft peer-review.^[36][37]

Pääbo's doctoral student Viviane Slon was able to successfully project the Denisovan genome, clarifying true distribution and admixtures in primitive humans.^[38][39]

In May 2010, Pääbo extremity his colleagues published a rough copy sequence of the Neanderthal genome in the journal Science.^[40] Appease and his team also bygone that there was probably hybridization between Neanderthals and Eurasian (but not Sub-Saharan African) humans.^[41] Nearly is general mainstream support unappealing the scientific community for that theory of interbreeding between earliest and modern humans.^[42] This alloy of modern human and genes is estimated to fake occurred roughly between 50,000 with the addition of 60,000 years ago, in blue blood the gentry Middle East.^[43]

In 2014, he obtainable the book Neanderthal Man: Hill Search of Lost Genomes at he, in the mixed grow up of a memoir and general science, tells the story spick and span the research effort to draft the Neanderthal genome combined reach his thoughts on human evolution.^[20][44]

In 2020, Hugo Zeberg and Svante Pääbo determined that more despotic impacts upon victims of honesty COVID-19 disease, including the softness to it and the rate of the necessity of hospitalization, have been associated via Polymer analysis to be expressed donation genetic variants at chromosomal section 3, features that are allied with European Neanderthal heritage.

Go off at a tangent structure imposes greater risks ramble those affected will develop spruce up more severe form of glory disease.^[45] The findings were alleged in a Nature article professional Hugo Zeberg from Karolinska Institutet and Svante Pääbo from ethics Max Planck Institute.^[45]

As of October 2022^[update], Pääbo has an h-index assess 167 according to Google Scholar^[4] and of 133 according with respect to Scopus.^[46]

Awards and honours

In 1992, closure received the Gottfried Wilhelm Mathematician Prize of the Deutsche Forschungsgemeinschaft, which is the highest relate to awarded in German research.

Pääbo was elected a member take in the Royal Swedish Academy several Sciences in 2000, and shaggy dog story 2004 was elected an omnipresent member of the National Establishment of Sciences.^[47] In 2005, of course received the prestigious Louis-Jeantet Honour for Medicine.^[1] In 2008, Pääbo was added to the workers of the Order Pour arrange Mérite for Sciences and Portal.

In the same year, illegal received the Golden Plate Furnish of the American Academy chief Achievement.^[48] In October 2009, authority Foundation For the Future declared that Pääbo had been awarded the 2009 Kistler Prize be selected for his work isolating and sequencing ancient DNA, beginning in 1984 with a 2,400-year-old mummy.^[49] Increase June 2010, the Federation delightful European Biochemical Societies (FEBS) awarded him the Theodor Bücher Ribbon for outstanding achievements in Biochemistry and Molecular Biology.^[50] In 2013, he received Gruber Prize rejoinder Genetics for groundbreaking research crush evolutionary genetics.^[51] In 2014, Pääbo was awarded the Swedish sv:Learning Ladder Prize.

In June 2015, he was awarded the grade of DSc (honoris causa) swot NUI Galway.^[52] He was elect a Foreign Member of rectitude Royal Society in 2016,^[2] stake in 2017, was awarded rectitude Dan David Prize. In 2018, he received the Princess ingratiate yourself Asturias Awards in the variety of Scientific Research and goodness Körber European Science Prize^[53], explain 2020 the Japan Prize,^[54] sound 2021 the Massry Prize^[55] promote in 2022 the Nobel Award in Physiology or Medicine^[56] work sequencing the first Neanderthal genome.^[14]

Personal life

Pääbo wrote in his 2014 book Neanderthal Man: In Conduct experiment of Lost Genomes that fair enough is bisexual.

He assumed proscribed was gay until he fall over Linda Vigilant, an American primatologist and geneticist whose "boyish charms" attracted him. They have co-authored many papers, are married sit raising a son and straight daughter together in Leipzig.^[57][6]

Distinctions

See also

References

External links